Cytochrome P450 1A2 (CYP1A2)

CYP1A2 is expressed in the liver and in other tissues, and it is responsible for the metabolism of a wide range of compounds, including drugs, environmental toxins, and other xenobiotics. For example, CYP1A2 is involved in the metabolism of caffeine, theophylline, and some carcinogens, as well as certain drugs used to treat heart disease, psychiatric disorders, and other medical conditions.

The activity of CYP1A2 is regulated by a number of factors, including genetic variations, environmental factors, and the presence of other drugs or compounds. Variations in the CYP1A2 gene can lead to differences in the activity and expression of the enzyme, and this can affect the metabolism of drugs and other compounds in the body.