Cytochrome P450 2B6 (CYP2B6)

CYP2B6 seems to produce oxylipins from polyunsaturated fatty acids and reduce diet-induced obesity.[1]

Adenosine N6-methylation (a.k.a. m6a, the most abundant internal RNA modification in eukaryotes[5]) seems to increase the expression of CP2B6.[2]

Lead decreases m6a, folic acid increases it.[4]

CYB2B6 doesn't seem to decrease with Non-alcoholic fatty liver disease, but rather increases in an attempt to reverse the condition.[3]

[1] https://pubmed.ncbi.nlm.nih.gov/36520866/

[2] https://pubmed.ncbi.nlm.nih.gov/36113565/

[3] https://pubmed.ncbi.nlm.nih.gov/19651758/

[4] https://www.sciencedirect.com/science/article/pii/S1756464620305004

[5] https://www.nature.com/articles/s41392-020-00450-x